Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy
نویسندگان
چکیده
Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers and clinicians to use Viscoelastic Tests (VET) such as Thromboelastography (TEG) to provide Targeted Thromboelastographic Hemostatic and Adjunctive Therapy (TTHAT) in a goal directed fashion to those trauma patients in need of hemostatic resuscitation. This review describes the utility of VETs, in particular, TEG, to provide TTHAT in trauma and acquired non-trauma-induced coagulopathy.
منابع مشابه
Thromboelastography to direct the administration of recombinant activated factor VII in a child with traumatic injury requiring massive transfusion.
OBJECTIVE To describe the use of thromboelastography (TEG) to direct hemostatic resuscitation in a child with traumatic injury requiring massive transfusion. DESIGN Case report. SETTING Level 1 pediatric trauma center in an academic tertiary care facility. PATIENT A 5-year-old boy with grade IV liver injury and right common hepatic artery laceration. INTERVENTION TEG-directed resuscitat...
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Amniotic fluid embolism (AFE) is an unusual cause of life threatening peri partum hemorrhage (PPH). AFE resuscitation is often associated with renal and respiratory insufficiency, and a coagulopathy similar to disseminated intravascular coagulation (DIC). Resuscitation requires immediate recognition and limited use of crystalloid. We present a case of PPH caused by AFE with resultant cardiac ar...
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25-35% of all seriously injured multiple trauma patients are coagulopathic upon arrival to the emergency department, and therefore early diagnosis and intervention on this subset of patients is important. In addition to standard plasma based tests of coagulation, the thromboelastogram (TEG) has resurfaced as an ideal test in the trauma population to help guide the clinician in the administratio...
متن کاملCurrent management of massive hemorrhage in trauma
Hemorrhage remains a major cause of potentially preventable deaths. Trauma and massive transfusion are associated with coagulopathy secondary to tissue injury, hypoperfusion, dilution, and consumption of clotting factors and platelets. Concepts of damage control surgery have evolved prioritizing early control of the cause of bleeding by non-definitive means, while hemostatic control resuscitati...
متن کاملTrauma Induced Coagulopathy: Prevention and Intervention
Trauma is associated with 1 in 10 deaths, with approximately 5.8 million mortalities annually worldwide [1]. Significant traumatic bleeding is associated with a poor outcome, with a total mortality of 30%, and is the leading cause of preventable death. Trauma and massive transfusion are associated with trauma induced coagulopathy (TIC), which triggers secondary hypoperfusion, dilutional coagulo...
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2016